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Canine Autoimmune Hemolytic Anemia (AIHA & IMHA) - Unfractionated heparin therapy
| Interesting study. Unfractionated heparin therapy has been shown to be a cost effective way to treat acute thromboembolism in humans. Big plus for veterinary care. This might be the next big thing in emergency care for Canine AIHA. my best patrice "J Am Anim Hosp Assoc. 2009 May-Jun;45(3):125-33. A prospective study of unfractionated heparin therapy in dogs with primary immune-mediated hemolytic anemia. Breuhl EL, Moore G, Brooks MB, Scott-Moncrieff JC. Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Lynn Hall, Purdue University, West Lafayette, Indiana 47907, USA. Unfractionated heparin therapy was initiated at a standard dosage of 300 IU/kg subcutaneously q 6 hours to 18 dogs with immune-mediated hemolytic anemia. Heparin's prolongation of activated partial thromboplastin time and change in factor Xa inhibition (anti-Xa activity) were serially monitored during the first 40 hours of therapy. During the initial 40 hours, only eight of 18 dogs had attained anti-Xa activities of > or =0.35 U/mL. No dogs had clinical signs of hemorrhage. Fifteen dogs survived to discharge; 11 dogs were alive at 1 year, and thrombosis was identified in three of six nonsurvivors that were necropsied. PMID: 19411648 [PubMed - in process]" |
| Patrice NYS |
| Thank you Patrice. I will pass this on to my vet. Brigitte & Kahlu |
| Brigitte BC Canada |
This thread was discussed on 12/05/2009
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