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Canine Autoimmune Hemolytic Anemia (AIHA & IMHA) - liposomal clodronate/leukeran
| Does anyone have any experience with either of the above therapies? Bear diagonosed approx 2 weeks ago, pred, imuran, cyclophosphamide, human immunoglobulin, 4 transfusions later and not past the critical stage. |
| stephanie |
| Stephanie, To the best of my knowledge liposomal clodronate is still in clinical trials. Here is an article on it that you might find useful. Copy and paste begins NOW: Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs. Mathes M, Jordan M, Dow S. Departments of Clinical Sciences, Colorado State University, Ft. Collins, CO 80523, USA. OBJECTIVES: Liposomal clodronate (dichloromethylene diphosphonate) has been used to deplete macrophages and block clearance of opsonized cells in mouse models of autoimmune disease. However, liposomal clodronate (LC) has not been previously evaluated in a large-animal spontaneous autoimmune disease model. Therefore, the safety and efficacy of LC treatment was assessed in normal dogs and in dogs with spontaneous autoimmune hemolytic anemia (AIHA). METHODS: LC was administered intravenously first to healthy dogs and then to dogs with spontaneous, severe AIHA to determine if the treatment was safe and could block clearance of opsonized red blood cells (RBCs) in vivo. Studies were also conducted to assess the in vitro effects of LC on dog macrophages and dendritic cells. RESULTS: Intravenous infusion of low doses of LC was well tolerated and blocked clearance of opsonized RBCs in normal dogs in vivo. LC was taken up by splenic macrophages and dendritic cells in vivo, and induced killing of macrophages and dendritic cells in vitro. Seven dogs with severe, spontaneous AIHA were treated with LC in a pilot study. Treatment was well tolerated, 2 of 7 LC-treated dogs with AIHA had a decrease in RBC clearance, and LC-treated dogs had significantly increased survival times compared to historical control dogs matched for disease severity. CONCLUSIONS: These results indicate that LC can be safely administered intravenously to dogs and that even relatively low doses are capable of blocking RBC clearance and improving outcomes in a spontaneous large-animal model of AIHA. Therefore, additional studies of LC for treatment of autoantibody-mediated cytopenias in dogs and humans may be warranted. PMID: 16982332 [PubMed - indexed for MEDLINE] End of copy and paste I found this info by going to http://www.ncbi.nlm.nih.gov/sites/entrez and typing in clodronate for treating canine aiha. |
| Joanne MN |
| Stephanie I neglected to tell you in my other post that if you have not read the SUCCESS STORIES at the Meisha's Hope AIHA/IMHA Web site as yet http://www.cloudnet.com/~jdickson/successstories.htm you might want to do so when you can. They will show you what has worked for other dogs in terms of treatment options as well as give you a lot of HOPE. Sometimes it can take a lot of time as well as trial and error to get a dog with AIHA/IMHA on the way to recovery. Keeping both you and your dear Bear in my thoughts and prayers |
| Joanne MN |
| Hi Stephanie, I looked into the same when Kent was sick, and found two clinical trials, one at colorado one in North Carolina. I called both, and Kent was not eligible to be in it because 1) they want to give the drugs within 3 days of diagnosis, and 2) at least for colorado you had to live nearby to bring the dog in - they did not ship to your vet. I'm sorry this is not the news you want to hear. You can google clinical trials, there might be a vet near you that is part of a network of vets trying to use this. I did hear that this drug works very well to increase initial survival rates while the other drugs kick in. Please hang in there, I am so sorry you are going through this right now. Christine and Kent |
| Christine Fl |
| Stephanie, I can't answer any of your questions - but wanted you to know that matilda spend the 1st week at Gulf Coast Critical Care in Houston - we live just outside of houston and work in houston. I'm sure there is more than one place that could help with this, but I just know that they were wonderful and from what they said they have a pretty good track record in dealing with this. I will keep you guys in my prayers. jeanne |
| Jeanne texas |
This thread was discussed between 26/05/2008 and 30/05/2008
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