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Canine Autoimmune Hemolytic Anemia (AIHA & IMHA) - Liposomal clodronate
| Hi I was wondering if anyone has heard of a drug called Liposomal clodronate and are they using it to treat AIHA dogs or are they just testing it? |
| Cheryl & Ginger Pineville pa |
| Cheryl, Not much time, here is first thing I found, sounds interesting: patrice http://www.ncbi.nlm.nih.gov/pubmed/16982332 2006 Oct "Liposomal clodronate (dichloromethylene diphosphonate) has been used to deplete macrophages and block clearance of opsonized cells in mouse models of autoimmune disease. However, liposomal clodronate (LC) has not been previously evaluated in a large-animal spontaneous autoimmune disease model. Therefore, the safety and efficacy of LC treatment was assessed in normal dogs and in dogs with spontaneous autoimmune hemolytic anemia (AIHA)." "CONCLUSIONS: These results indicate that LC can be safely administered intravenously to dogs and that even relatively low doses are capable of blocking RBC clearance and improving outcomes in a spontaneous large-animal model of AIHA. Therefore, additional studies of LC for treatment of autoantibody-mediated cytopenias in dogs and humans may be warranted." |
| Patrice NYS |
| Put more simply: LC is injected into the system and acts like a trojan horse. It attracts the bodies macrophages to it, gets the macrophage to "bite" and then destroys the macrophage. The red blood cells that have been marked (opsonized) for destruction escape being attacked by the macrophages. Liposomes are used to hide the clondronate in the blood stream (a fat barrier to the water of the blood, oil and water don't mix) so it can move around in the bloodstream without interference. Pretty clever technique. I don't know how they "clear" the body of the liposomes after a period of time. I guess that would be where the side effects might be. We all rely on our macrophages to help protect us against foreign invaders like bacteria. Destroying macrophages might not be a good idea if it continued. patrice |
| Patrice NYS |
| Cheryl, If I am not mistaken this is the medication that I had been investigating for Barkley when he was struggling so. It was in clinical trial but because Barkley had already begun treatment with the other medications he could not qualify for the clinical trial. I am thinking that the trial was going on at one of the veterinary schools in Colorado but I am not absolutely certain. You can get more information if you do web searching about this one and it may be that one of the researchers funded through the Morris Animal Foundation was working with this medication, so you might find more info through that website. Hope that helps. Cheryl (and always Barkley) |
| Cheryl Medford |
| I am so hoping that maybe this type of treatment will someday buy some much needed time until the other medicines can kick in. Thanks for your information and I will see if I can find out more information about it and if they are indeed are still testing it on AHIA dogs. Cheryl & Ginger |
| Cheryl & Ginger Pineville PA |
| The study that Patrice referenced in her post was sponsored by the Meisha’s Hope AIHA/IMHA Fund #338 at Morris Animal Foundation http://www.morrisanimalfoundation.org/meisha You can learn about it here http://www.morrisanimalfoundation.org/completed_studies click on canine, then blood disorders, then D02CA-025 There is currently another study being done on LC at CSU as well which is in it’s second year but I think the dog needs to be in the study as soon as it is diagnosed before it is started on other medications. From what I hear this treatment seems promising |
| Joanne MN |
This thread was discussed between 11/09/2008 and 12/09/2008
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