Canine Autoimmune Hemolytic Anemia (AIHA & IMHA) - Has anyone ever heard of Marin.

Has anyone ever heard of Marin. I told the vet about milk thisle and he told me that it is ok to give to my dog. He said that he had some there and would give it to me to give to Oliver. When I read the label it said nothing about milk thisle. It's active ingredients are Vitamin E, Silybin A+B, and Zinc. When I was reading about this diseas something that it said that caused this disease was zinc poisoning. I am not sure if this is something I want to be giving to Oliver.

Mark
mark pennsylvania


Mark, I think zinc poisioning is related to dogs eating pennys, but there may be another cause hopefully someone else can chime in.

Laurie
Laurie CA


Mark,
Marin is a veterinary formulation (Nutramax) of the essence of milk thistle: silymarin. This is a commonly used supplement to aid the liver. This company also manufactures Denosyl, which is a formulation of Sam-e, for the same purpose.
See: http://www.nutramaxlabs.com/products/animal/liver/liver.asp

Denamarin, also made by Nutramax, is a veterinary formulation of both silymarin and Sam-e that is superior in it's ability to aid the liver while it is processing the high doses of prednisone necessary to suppress the immune system.
See: http://www.nutramaxlabs.com/products/animal/denamarin/denamarin_faq.asp

I used Denamarin, despite its expense, for Chance when he was on very high doses of prednisone. It assists the liver by helping it replace damaged cells.

If I were you I would not hesitate to use this supplement if you can afford it. The liver enzymes (seen on a chemical screen test) that show damage to the liver can become very high during immunosuppressive treatment. The liver is regenerative and will recover eventually in most cases. Your vet, if they have not treated many AIHA dogs, might become alarmed at how high these numbers can be. Try not to worry too much about that right now.

Here is my favorite explanation of how zinc coins can cause this anemia problem:
http://www.marvistavet.com/html/zinc_poisoning.html

If there has been an x-ray showing a zinc coin in the digestive tract then that would be the clinical proof that this has caused this condition. If there hasn't been any sign or suspicion of a coin, then there should be no worry that this is the cause.

The supplement zinc is "an essential trace element, necessary for sustaining all life." In the small dose that would be in this supplement, I would not worry.

If you have any more questions please don't hesitate to ask.
my best
patrice

Patrice NYS


Yes, Willow was on Marin and also Denosyl for her liver while on Prednisone. She actually started it after we found liver inflammation and I have to say, it worked EXTREMELY well. Her levels were back to normal within two weeks.
Lori USA


This thread was discussed between 20/12/2008 and 21/12/2008

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