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Canine Autoimmune Hemolytic Anemia (AIHA) - MAF Study of Clopidogrel in dogs
| Each year when I release money from the Meisha’s Hope AIHA/IMHA fund #338 at MAF for a study I have to sign a confidentially agreement that I will not divulge information that I receive about the study until one year after the study has been completed. I receive periodic updates on these studies from time to time as the information becomes available. I received such info at the end of last week on a study that Meisha’s Hope co-sponsored in 2007 which was just completed on 11/30/08. There were 3 pages of very technical information but the following paragraph I am allowed to share with donors. I was also told that the first draft of manuscript is nearing completion and will be submitted to an appropriate veterinary journal in early 2009. Hopefully in the future this will prove to be an effective way to prevent or manage blood clots in AIHA/IMHA dogs. Here is the update I was told I could share with donors and others who are interested. D07CA-303: Pharmacokinetic and Pharmacodynamic Study of Clopidogrel in Dogs UPDATE: Many critically ill dogs are at significant risk for developing blood clots (thromboembolism) that may cause serious complications such as interrupted blood flow to the lungs. Historically drugs such as aspirin and heparin have been used to treat dogs at risk of clotting, but these drugs carry significant risk of bleeding or gastrointestinal complications. In this Morris Animal Foundation/ Meisha’s Hope AIHA/IMHA Fund #338 -funded study, researchers at the University of Georgia investigated the drug, clopidogrel (Plavix®), which decreases the activity of blood platelets. They successfully established that clopidogrel was safe and effective for decreasing platelet activity in dogs. These researchers also created a blood test to evaluate circulating levels of the drug. This test will help to relate the concentrations of drug by-products to the drug effects in the body, and will be a tool for future studies. This study investigated clopidogrel in healthy dogs, so the next step is to apply what they have learned to critically ill dogs. The patients likely to benefit from the clinical effects of clopidogrel are dogs suffering from diseases such as immune-mediated hemolytic anemia.. This project developed a methodology that could also be incorporated into studying the effects of clopidogrel in other species. To learn how you can donate to the Meisha’s Hope AIHA/IMHA Fund #338 at Morris Animal Foundation, visit these Web pages: http://www.cloudnet.com/~jdickson/newhope.htm http://www.morrisanimalfoundation.org/meisha |
| Joanne MN |
| Joanne, Thank you for sharing. I always look to see what they might be researching. With the economy tanking like it is I haven't been able to make as many dontaions as I have previously but hope to have that caught up before years end. Someday we will beat this! Penny |
| Penny Lytle Creek Calif |
| Joanne -- thank you so much for sharing. The vets who treated our Wiley, including Dr. Matthew Antkowiak who was a finalist for one of the Meisha's Hope awards a few years ago, thought that she had some kind of clot that caused the "event" that left her paralyzed on day three of her fight against IMHA. So, this whole clotting issue, and the effort to find a treatment for this, is important to me. Wiley took aspirin during her effort to fight IMHA, but it alone apparently was not enough to prevent clotting. I do hope to hear more about this someday. Thank goodness for the Meisha's Hope Fund and the MAF, because we need them to help us find a way to a cure. |
| Brenda VA |
| Awesome! It's good to know that we may have one more tool to use in the battle. It makes total sense, too. melissa and tiggs |
| melissa slc |
This thread was discussed between 09/02/2009 and 10/02/2009
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